PhD Molecular Physiology · Science Communicator

Science, Soul
& Sustainability

Peer-reviewed molecular science. For the woman navigating menopause, the parent building an extraordinary child, and anyone growing with biochemical intention.

Peer-Reviewed Sources Primary Bench Research Published Author BloomBrilliant.org

Read the Science Download Free Guide

University of Rochester

Salivary Acinar Cell Biology & Transgenic Mouse Models

Post-doctoral research investigating salivary gland physiology using transgenic mouse models.
Published in peer-reviewed journals.

Nguyen HV, Stuart-Tilley A, Alper SL, Melvin JE. Cl(-)/HCO(3)(-) exchange is acetazolamide sensitive and activated by a muscarinic receptor-induced [Ca(2+)](i) increase in salivary acinar cells. Am J Physiol Gastrointest Liver Physiol. 2004 Feb;286(2):G312-20.

Nehrke K, Arreola J, Nguyen HV, Pilato J, Richardson L, Okunad G, Baggs R, Shull GE, Melvin JE. Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem. 2002 Jun;277(26):23604-11.

Gonzalez-Begne M, Nakamoto T, Nguyen HV, Stewart AK, Alper SL, Melvin JE. Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice. J Biol Chem. 2007 Nov;282(48):35125-32.

Arreola J, Begenisich T, Nehrke K, Nguyen HV, Park K, Richardson L, Yang B, Schutte BC, Lamb FS, Melvin JE. Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene. J Physiol. 2002 Nov;545(1):207-16.

Krane CM, Melvin JE, Nguyen HV, Richardson L, Towne JE, Doetschman T, Menon AG. Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation. J Biol Chem. 2001.

Melvin JE, Nguyen HV, Nehrke K, Schreiner CM, Ten Hagen KG, Scott W. Targeted disruption of the Nhe1 gene fails to inhibit beta-1-adrenergic receptor-induced parotid gland hypertrophy. Am J Physiol Gastrointest Liver Physiol. 2001;280(4):G694-G700.

Melvin JE, Nguyen HV, Evans RL, Shull GE. What can transgenic and gene-targeted mouse models teach us about salivary gland physiology? Advances in Dental Research. 2000 Dec;14:5-11.

Nguyen HV, Shull GE, Melvin JE. Muscarinic receptor-induced acidification in sublingual mucous acinar cells: loss of pH recovery in Na+/H+ exchanger-1 deficient mice. J Physiol. 2000 Feb;523(1):139-46.

Evans RL, Park K, Turner RJ, Watson GE, Nguyen HV, Dennett MR, Hand AR, Flagella M, Shull GE, Melvin JE. Severe impairment of salivation in Na+/K+/2Cl- cotransporter (NKCC1)-deficient mice. Journal of Biological Chemistry. 2000 Sep 1;275(35):26720-26726.

University of Southern California

Epithelial Barrier Integrity Under Hypoxic Stress

Doctoral research examining salivary epithelial cells and barrier function under conditions of hypoxic stress.

Nguyen HV, Chen JL, Zhong J, Kim KJ, Crandall ED, Borok Z, Chen Y, Ann DK. SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Am J Pathol. 2006 May;168(5):1452-63.

Chung V, Zhou B, Liu X, Zhu L, Boo LM, Nguyen HV, Ann DK et al. SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone. Mol Cancer Ther. 2006;5(3):533-40.

Nguyen HV et al. [European Journal of Oral Sciences. 2007]. DOI: 10.1111/j.1600-0722.2007.00421.x

BloomBrilliant.org

Science Communication · Three Pillars · One Scientific Life

Women's health and menopause · Early childhood education · Bioactive nutrient-rich living

  
    ●BSc Biochemistry
    ●PhD Molecular Physiology
    ●University of Rochester
    ●University of Southern California
    ●18 Years Curriculum Design
    ●Science Communicator

Three Pillars. One Scientific Life.

Evidence-based science across three chapters of a single scientific journey.

Pillar One

Women's Health & Menopause

Molecular science for every woman navigating the menopausal transition. Evidence-based, source-transparent and written for the woman who wants to understand.

Read the Science →

Pillar Two

Education & College Readiness

The NGS whole-child curriculum. Eighteen years of documented outcomes. The framework that builds what no school and no AI can replicate.

Explore the Framework →

Pillar Three

Grow with Purpose

Biochemical intention applied to everything grown and prepared at home. The garden as laboratory. The kitchen as analytical suite.

Grow with Intention →

Free Download · Pillar One

Five Things Your Doctor Has Never Told You
About Perimenopause

A one-page evidence-based reference card covering the most important things the published science confirms that most clinical appointments never address. Download instantly.

Your information is never shared. You may unsubscribe at any time.

Science, Soul & Sustainability